DSIP

Research

Delta Sleep-Inducing Peptide

Category
Sleep & Recovery
Aliases
Wagner-Jurgens peptide
Administration
Subcutaneous injection (research), Intranasal (research)

How it works

  1. Modulates hypothalamic-pituitary-adrenal (HPA) axis stress hormone release

    It appears to help regulate your body's central stress-hormone system.

  2. Originally reported to increase delta-wave (slow-wave) sleep, though replication has been inconsistent

    Early studies suggested it deepened sleep, but later attempts to reproduce those results have been mixed and inconsistent.

  3. May influence pain perception and circadian rhythm regulation

    It may also play a role in pain sensitivity and your internal body clock, though this is not firmly established.

Result

Originally believed to deepen sleep, though later research suggests its real effect may be calming the body's stress response rather than sleep itself. Some users report feeling calmer or less wound up, though a consistent, noticeable improvement in sleep itself is not well supported by the evidence.