Melanotan I

FDA Approved

Melanotan I (Afamelanotide)

Aliases
Afamelanotide, Scenesse
Administration
Subcutaneous implant (FDA-approved route)

Overview

Melanotan I, marketed as the FDA-approved implant Scenesse, stimulates melanin production to protect patients with erythropoietic protoporphyria — a rare genetic disorder causing severe pain on sun exposure — from light-induced skin damage. It is chemically related to, but distinct from, the more potent and unapproved Melanotan II, which is widely sold illicitly for cosmetic tanning.

Treatments studied

Treatment categories

Erythropoietic protoporphyria (FDA approved)

Its only FDA-approved use, boosting protective skin pigment for patients who cannot tolerate sunlight.

Cosmetic tanning

Stimulates melanin production, producing a tan effect independent of UV exposure.