PT-141

FDA Approved

Bremelanotide

Category
Sexual Health
Aliases
Bremelanotide, Vyleesi
Administration
Subcutaneous injection (approved), Intranasal (research)

How it works

  1. MC3R and MC4R agonism in hypothalamus

    It activates specific brain receptors in the hypothalamus that are tied to sexual desire.

  2. Increases central dopamine signaling

    It boosts dopamine activity in brain regions linked to motivation and reward.

  3. No sexual stimulation required

    It can produce an effect on its own, without needing physical stimulation to work.

  4. Non-vascular mechanism

    It works through the brain rather than by increasing blood flow, which is how most other sexual-function medications work.

Result

Restored sexual desire, achieved through a direct effect on the brain rather than blood flow. The felt effect is an increase in sexual interest and arousal itself, rather than a physical change — it works on desire, not just physical response.