Semaglutide

FDA Approved

Semaglutide

Aliases
Ozempic, Wegovy, Rybelsus
Administration
Subcutaneous injection (weekly), Oral tablet (daily)

How it works

  1. GLP-1 agonism — glucose-dependent insulin secretion

    It copies a natural gut hormone that tells the pancreas to release insulin, but only when blood sugar is actually high.

  2. Suppresses glucagon

    It reduces a hormone that would otherwise raise blood sugar, helping keep levels steady.

  3. Central appetite suppression

    It acts on brain regions that control hunger, helping reduce appetite.

  4. Slows gastric emptying

    It slows digestion so food stays in the stomach longer, extending the feeling of fullness.

  5. Direct cardioprotective effects

    It appears to directly benefit heart and blood vessel health, separate from its effects on weight and blood sugar.

Result

Meaningful weight loss, improved blood sugar control, and a lower risk of heart-related events over time. Day to day, this usually feels like significantly reduced appetite and fewer food cravings, with gradual, visible weight loss over time.