Sermorelin

FDA Approved

Sermorelin (GRF 1-29)

Category
Growth Hormone
Aliases
GRF 1-29, Geref
Administration
Subcutaneous injection

Overview

Sermorelin is the first 29 amino acids of natural GHRH — the shortest fragment that retains full biological activity. It was FDA approved in the 1990s under the brand name Geref for diagnosing and treating growth hormone deficiency in children, though the manufacturer discontinued the product for business reasons. It remains available today through compounding pharmacies.

Treatments studied

Treatment categories

Growth hormone deficiency

Was FDA approved specifically to diagnose and treat inadequate growth hormone production in children.

Age-related growth hormone decline (off-label)

Stimulates the body's own growth hormone production through its natural pituitary pathway, rather than replacing growth hormone directly.