Dihexa
ResearchDihexa (PNB-0408)
- Category
- Cognitive & Neuroprotection
- Aliases
- PNB-0408
- Administration
- Oral (research), Intranasal (research)
Overview
Dihexa is a synthetic compound derived from angiotensin IV research, engineered to be orally active and blood-brain-barrier penetrant while retaining potent activity on the hepatocyte growth factor (HGF)/c-Met pathway. Although sometimes marketed as a 'peptide,' its structure is modified well past what's chemically considered a peptide, making it a small molecule. All published data is from rodent studies.
Treatments studied
Treatment categories
Cognitive impairment (preclinical)
Promoted a dramatic increase in new synaptic connections in rodent brain models.
Alzheimer's disease
Targets the HGF/c-Met pathway implicated in neurodegeneration, though only in animal studies to date.