FOXO4-DRI

Preclinical

FOXO4-D-Retro-Inverso Peptide

Aliases
FOXO4-DRI, Proxofim
Administration
Subcutaneous injection (preclinical/animal research only)

Documented benefits

Tier 1 · Peer-reviewed / regulatory

Benefit categories

Longevity & Anti-Aging

FOXO4-DRI's defining research application — one of the most studied synthetic senolytic peptides in preclinical aging research.

Senescent cell clearance

Its core, defining mechanism — selectively triggering apoptosis in senescent ("zombie") cells rather than broadly toxic cell killing.

Anti-aging

Targets senescent cell accumulation directly, one of the hallmark drivers of tissue aging, distinct from the mitochondrial or telomere-focused mechanisms of peptides like SS-31 or Epithalon.

Reduced oxidative stress

Clearing senescent cells reduces the inflammatory, oxidative signals ("SASP") those cells continuously release into surrounding tissue.