MOTS-c

Research

Mitochondrial ORF of 12S rRNA-c

Aliases
Mitochondrial peptide MOTS-c
Administration
Subcutaneous injection

Overview

Recently discovered mitochondrially-encoded peptide functioning as a metabolic regulator. Activates AMPK, improves insulin sensitivity, and extends lifespan in mouse models.

Treatments studied

Treatment categories

Age-related decline

Activates AMPK, a cellular energy pathway that becomes less responsive with age.

Exercise intolerance

Mimics several of the metabolic adaptations normally triggered by physical exercise.

Insulin resistance

Improves glucose uptake into cells by upregulating GLUT4 transporters.

Longevity

Extended lifespan in mouse models by activating cellular stress-response and energy pathways.

Metabolic syndrome

Improves multiple components of metabolic dysfunction simultaneously by targeting AMPK signaling.