SS-31

Clinical Trials

Elamipretide (MTP-131)

Aliases
Elamipretide, MTP-131, Bendavia
Administration
Subcutaneous injection, IV infusion (clinical)

Overview

Mitochondria-targeted peptide that selectively binds cardiolipin to stabilize cristae architecture and restore electron transport chain efficiency. Reverses age-related mitochondrial dysfunction.

Treatments studied

Treatment categories

Age-related decline

Restores efficiency to aging mitochondria, a key driver of age-related cellular decline.

Heart failure

Stabilizes cardiolipin in heart-cell mitochondria, improving the energy supply to cardiac muscle.

Longevity

Targets mitochondrial dysfunction, one of the most well-established hallmarks of biological aging.

Mitochondrial disease

Directly addresses the mitochondrial membrane defects underlying many mitochondrial disorders.

Sarcopenia

Improves muscle mitochondrial function, which is closely tied to age-related muscle loss.