Retatrutide

How it works

1. Dual GIP and GLP-1 receptor agonism (shared with tirzepatide)

   It copies two gut hormones at once, the same combination tirzepatide uses.

2. Additional glucagon receptor agonism, increasing energy expenditure

   It also activates a third hormone pathway that raises how many calories your body burns at rest — a mechanism no other approved obesity drug currently has.

3. Hypothalamic appetite suppression

   It acts on the brain's hunger center to reduce appetite.

4. Improves insulin sensitivity and beta-cell function

   It helps your body's cells respond better to insulin.