SLU-PP-332

Research

SLU-PP-332

Aliases
Exercise mimetic ERR agonist
Administration
Oral (research, animal studies)

Overview

SLU-PP-332 is a synthetic small molecule that activates the estrogen-related receptors (ERRα/β/γ), the same transcriptional pathway naturally activated by endurance exercise. In mouse studies, it increased running endurance and induced a slow-twitch, fat-burning muscle fiber profile without any actual exercise, earning it the 'exercise mimetic' label, though it has never been studied in humans.

Treatments studied

Metabolic syndrome

Activates the same genetic pathway triggered by endurance exercise, improving metabolic markers in mice.

Exercise intolerance

Increased exercise capacity in mouse studies without requiring any actual physical training.