VIP

Research Phase

Vasoactive Intestinal Peptide

Category: Immune & Inflammatory
Aliases: Vasoactive Intestinal Polypeptide, Aviptadil
Administration: Intravenous infusion (studied), Subcutaneous injection (research)

Documented benefits

Tier 1 · Peer-reviewed / regulatory

Benefit categories

Anti-Inflammatory & Pain Relief
Immune Function & Defense

Immune & Inflammatory

VIP's defining research application — a naturally occurring neuropeptide with broad anti-inflammatory signaling across the gut, lungs, and immune system.

Anti-inflammatory

Its core, defining mechanism — VPAC receptor activation that broadly calms inflammatory cytokine activity across multiple organ systems.

Immune modulation

Because VIP receptors sit on immune cells directly, it can both calm an overactive inflammatory response and support normal immune signaling, depending on context.