Semax

Approved (Russia/Ukraine)

Semax

Aliases
ACTH 4-10 analog, Семакс
Administration
Intranasal spray, Subcutaneous injection

Documented benefits

Tier 1 · Peer-reviewed / regulatory

Cognitive & Neuroprotection

Semax's defining research application — originally developed in Russia specifically for post-stroke neurological recovery.

BDNF elevation

Produces a notably sharp rise in BDNF within the hippocampus, the brain region tied to memory formation.

Cognitive enhancement

Supports mental clarity through combined effects on serotonin, dopamine, and BDNF systems.

Improved memory

Its hippocampal BDNF effect directly supports memory formation and retention.

Improved focus

Users report steadier concentration, consistent with its dopamine and serotonin synthesis effects.

Neuroprotection

Upregulates VEGF, supporting blood vessel and tissue repair in damaged neural tissue.

Stroke recovery support

Its original, defining clinical use in Russia — supporting neurological repair following stroke.