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Weight Management & Obesity

5-Amino-1MQ

Weight Loss & Metabolism

Research

A small-molecule compound (not actually a peptide) that blocks an enzyme tied to fat storage. Popular in longevity circles, but only tested in animals so far.

AOD-9604

Weight Loss & Metabolism

Research

A lab-made fragment of growth hormone, designed to burn fat without any of growth hormone's other effects. Human trials didn't show it actually works better than placebo.

Cagrilintide

Weight Loss & Metabolism

Clinical Trials

A long-acting amylin-mimicking peptide best known as half of Novo Nordisk's CagriSema combo. Works alongside GLP-1 drugs to suppress appetite even further.

Mazdutide

Weight Loss & Metabolism

Research Phase

A dual GLP-1/glucagon receptor agonist approved in China for weight management, combining appetite suppression with increased energy expenditure.

Retatrutide

Weight Loss & Metabolism

Clinical Trials

An experimental triple-hormone injection from Eli Lilly showing the biggest weight-loss results of any drug tested so far. Not yet approved — still in late-stage trials.

Semaglutide

Weight Loss & Metabolism

FDA Approved

The FDA-approved GLP-1 behind Ozempic and Wegovy. Reduces appetite, blood sugar, and heart disease risk.

Survodutide

Weight Loss & Metabolism

Research Phase

An investigational dual GLP-1/glucagon receptor agonist in Phase 3 trials, designed to combine appetite suppression with increased calorie burning.

Tesamorelin

Growth Hormone

FDA Approved

One of the few growth-hormone peptides that's actually FDA approved — but only for a specific fat-redistribution condition in HIV patients. Any other use is off-label.

Tirzepatide

Weight Loss & Metabolism

FDA Approved

An FDA-approved weekly injection for diabetes and weight loss. Delivers the strongest results of any approved weight-loss medication to date.