Pentosan Polysulfate

FDA Approved

Pentosan Polysulfate Sodium

Aliases
PPS, Elmiron
Administration
Oral, Intraarticular injection (research)

Overview

Polysaccharide with cartilage-protective and anti-inflammatory properties. FDA approved for interstitial cystitis. Emerging research supports joint regeneration applications, particularly for hip dysplasia and early osteoarthritis.

Treatments studied

Treatment categories

Interstitial cystitis

The only FDA-approved use, helping restore the protective bladder lining thought to be damaged in this condition.

Joint degeneration

Stimulates cartilage cells to produce more of the cushioning material joints need.

Osteoarthritis

Reduces cartilage-degrading enzyme activity while supporting new cartilage matrix production.