Pentosan Polysulfate

FDA Approved

Pentosan Polysulfate Sodium

Aliases
PPS, Elmiron
Administration
Oral, Intraarticular injection (research)

Documented benefits

Tier 1 · Peer-reviewed / regulatory

Benefit categories

Recovery & Healing

Pentosan Polysulfate's defining research application — one of the few FDA-approved compounds in this category.

Anti-inflammatory

Reduces inflammation through a heparin-like mechanism, distinct from the pathways used by peptides like BPC-157.

Cartilage protection

Inhibits the enzymes responsible for breaking down existing cartilage.

Cartilage regeneration

Stimulates cartilage-producing cells (chondrocytes) to generate more of the tissue that cushions joints.

Joint lubrication

Supports the quality of synovial fluid, the substance that reduces friction inside joints.

Pain reduction

Reduces joint pain as a downstream effect of reduced inflammation and improved cartilage integrity.