Pentosan Polysulfate

FDA Approved

Pentosan Polysulfate Sodium

Aliases
PPS, Elmiron
Administration
Oral, Intraarticular injection (research)

How it works

  1. Stimulates chondrocyte proteoglycan synthesis

    It encourages cartilage cells to produce more of the cushioning material that keeps joints springy.

  2. Inhibits proteolytic enzymes degrading cartilage

    It blocks enzymes that would otherwise break down and wear away cartilage.

  3. Anti-inflammatory via heparin-like activity

    It calms inflammation using a mechanism similar to the blood thinner heparin.

  4. Promotes synovial fluid quality

    It helps improve the lubricating fluid inside joints, reducing friction and stiffness.

Result

Reduced joint pain and better-cushioned cartilage, along with relief from chronic bladder pain. People typically feel less pain and stiffness during movement, and for bladder-related use, reduced pelvic pain and urinary urgency.